proprotein convertase 2 การใช้

In humans, proprotein convertase 2 is encoded by the " PCSK2 " gene.
Glucagon is generated from the cleavage of proglucagon by proprotein convertase 2 in pancreatic islet ? cells.
Another prohormone convertase, proprotein convertase 2 plays a more minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis.
When prodynorphin is cleaved during processing by proprotein convertase 2 ( PC2 ), multiple active peptides are released : dynorphin A, dynorphin B, and vesicles in the presynaptic terminal.
Once released from the signal peptide, it undergoes additional proteolysis and posttranslational modification " ( indicated by "'^ "') " . 11 amino acids are removed from the N-terminus by the enzyme proprotein convertase 2 ( PC2 ) while 16 are removed from the C-terminus of the proIAPP molecule by proprotein convertase 1 / 3 ( PC1 / 3 ).